No.135
Synthesis of α-Diazoketones
| I0643 | (Isocyanoimino)triphenylphosphorane (1) |
5g |
Compound 1 is a useful reagent for the synthesis of diazoketones. The compound 1 was reacted with acid chlorides followed by hydrolysis and then treated with triethylamine and a catalytic amount of p-toluenesulfonyl chloride to give diazoketones 2.1) Moreover, the compound 1 has been used for the synthesis of heterocyclic compounds 3 and 4.2)
References
1) Synthesis of α-diazoketones
a) E. Aller, P. Molina, Á. Lorenzo, Synlett, 2000, 526; b) M. M. Bio, G. Javadi, Z. J. Song, Synthesis, 2005, 19.
2) Synthesis of heterocyclic compounds
a) A. Souldozi, A. Ramazani, Tetrahedron Lett., 2007, 48, 1549; b) A. Souldozi, A. Ramazani, N. Bouslimani, R. Welter, Tetrahedron Lett., 2007, 48, 2617.
a) E. Aller, P. Molina, Á. Lorenzo, Synlett, 2000, 526; b) M. M. Bio, G. Javadi, Z. J. Song, Synthesis, 2005, 19.
2) Synthesis of heterocyclic compounds
a) A. Souldozi, A. Ramazani, Tetrahedron Lett., 2007, 48, 1549; b) A. Souldozi, A. Ramazani, N. Bouslimani, R. Welter, Tetrahedron Lett., 2007, 48, 2617.
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