Application

No.134
Active Esterification
C1957 Chloro-N,N,N',N'-tetramethylformamidinium Hexafluorophosphate 5g
1g

Various types of condensing agents for esterification are known, and the amidinium type is one of these. For example, chloro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate (1) reacts with 2-mercaptopyridine (2) to give the thiouronium salt 3. The compound 3 will easily react with carboxylic acids to give thioesters, like 4, in high yield.

References

Synthesis of 2-pyridinethiol esters
N. Scardovi, P. P. Garner, J. D. Protasiewicz, Org. Lett., 2003, 5, 1633.

Related Compounds

C1651 2-Chloro-1,3-dimethylimidazolinium Hexafluorophosphate 25g
5g
C1379 1-(Chloro-1-pyrrolidinylmethylene)pyrrolidinium Hexafluorophosphate 5g
B1657 O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate (HBTU) 25g
5g
C1988 O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate (HCTU) 5g
1g
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