No.106
A Soft Nucleophile for Palladium(0)-Catalyzed
Addition to Allylic Systems
Addition to Allylic Systems
| P1353 | Methyl Phenylsulfonylacetate (1) |
5g |
The product 1 reacts with allylic acetate 2 as a soft nucleophile in the presence of a palladium(0) catalyst and afford 2-phenylsulfonyl (4E)-enoate 3, which followed by desulfonation leads to the construction of trans-4-enoate 4.
References
1) A stereocontrolled synthesis of trans-allylic amines
W. J. Thompson, T. J. Tucker, J. E. Schwering, J. L. Barnes, Tetrahedron Lett., 31, 6819 (1990).
W. J. Thompson, T. J. Tucker, J. E. Schwering, J. L. Barnes, Tetrahedron Lett., 31, 6819 (1990).
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