Introduction of fluorine into a certain position of bioactive compound such as a pharmaceutical and an agricultural chemical may remarkably reduce the toxicity of the compound, or improve the efficiency of medicine. This is due to the mimic and blocking effect characterized by fluorine. Many compounds, such as 5-fluorouracil, have been reported as success case.
Attempts to efficiently synthesize fluorine-containing compounds are performed in many fields. Methods to introduce fluorine into a certain position through the use of fluorinating agents or the use of fluorine-containing building blocks have been reported.

Recently, triethyl 2-fluoro-2-phosphonoacetate has increasingly been utilized as a useful bifunctional fluorine-containing intermediate. This compound is very useful in the generation of physiologically active compounds because it can generate α-fluoro-α,β-unsaturated ester from the reaction with carbonyl compounds in the presence of a base. A subsequent reduction of the above ester leads to the corresponding aldehyde or alcohol. As examples, vitamin A derivatives¹⁾, pheromone of insect origin, synthesis of Pyrethroide having insecticidal efficacy, etc., can be given.

Building Blocks

Electrophilic Fluorinating Reagents

Nucleophilic Fluorinating Reagents

Fits Reagents

Building Blocks

F0518	D2525	D2524
T1570	T0435	M1193
T1604	T1512	B1801
F0340	B1673	C0990
C1503	F0283	D2523
D1423	E0663	D2782
E0547	T0810	B1463
C1458	C1467	D2530
D2498	F0030	T0432
F0341	H0598	T1245
C1586	F0311	T1516
C0991	T0791	T0433

Electrophilic Fluorinating Reagents

F0346	F0328	F0344
F0334	F0343	F0327
F0342	F0358	F0335

Nucleophilic Fluorinating Reagents

D1868	D2831	B2440
T1295	T1909	T1592
T1635	T1338	T1339
T2027	T2026	T2023
T2022

Fits Reagents

P1081	P1080	P1659
P1082