Higher Fatty Acids & Higher Alcohols
As studies of the processes progress, it gradually has been revealed that higher fatty acids play the important roles functionally as the components of lipids such as triglycerides, phospholipids and glycolipids which exist in the living body. Docosahexaenoic acid (DHA) makes improvements in learning ability, and Eicosapentaenoic acid (EPA) controls arteriosclerosis. As such, the higher fatty acids are found to have the bioactivities, therefore further studies of them are taking place.
Docosapentaenoic acid (DPA) is an ω3 unsaturated higher fatty acid, which is classified as same as EPA and DHA. The study progress delayed as it is merely exist. Recently, the potency of DPA stimulation of vascular endothelial cell (VEC) migration is reported as 100 times greater than that of EPA.1) DPA is now coming to the forefront of research. According to the report, when the enzymatic inhibitor with the function of converting EPA into DPA and EPA are administered together, it can not get the VEC migration effect. It is therefore presumed that the EPA stimulation effect of VEC migration occurs as part of administered EPA is converted to DPA. Furthermore, DPA demonstrates remarkable properties of controlling the expression of KDR, one of the receptors of VEGF which promotes antiangiogenesis function, and also has the possibilities of antithrombotic ability.2,3) Amongst all the important findings, its antiangiogenesis ability is expected to be effective for cancer treatment. Therefore, DPA is attracting much of the hottest attentions now. Our DPA ethyl ester is developed by the original technology to derive the highly purified standard. Therefore, it is desirable for use in experiments at cellular levels.
Most of the higher fatty acids, unsaturated higher fatty acids, and their esters and higher alcohols listed here are all ranked as highly purified quality products.
Unsaturated Higher Fatty Acids (including thier Me & Et Esters)
Saturated Higher Fatty Acids
Higher Alcohols
Literature
1) T. Kanayasu-Toyoda, I. Morita, S. Murota, Prostaglandins, Leukot. Essent. Fatty Acids, 1996, 54, 319.
2) S. Akiba, T. Murata, K. Kitatani, T. Sato, Biol. Pharm. Bull., 2000, 23, 1293.
3) M. Tsuji, I. Morita, S. Murota, Kekkan (Japanese Journal of Circulation Research), 2002, 25, 5.